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CANCER MODELS

A new sophistication for breast cancer PDXs

Nature Cancer volume 3, pages 138–140 (2022)Cite this article

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New research shows that comprehensively characterized patient-derived xenografts (PDXs) of breast cancer can be adapted to high-throughput drug screening and can be used as personalized patient avatars to inform clinical decision-making. This work substantially enhances the repertoire and sophistication of PDXs for research into breast cancer.

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Fig. 1: The establishment and applications of PDX and PDxO models.

References

  1. Woo, X. Y. et al. Nat. Genet. 53, 86–99 (2021).

    Article  CAS  Google Scholar 

  2. Bruna, A. et al. Cell 167, 260–274.e222 (2016).

    Article  CAS  Google Scholar 

  3. DeRose, Y. S. et al. Nat. Med. 17, 1514–1520 (2011).

    Article  CAS  Google Scholar 

  4. Sachs, N. et al. Cell 172, 373–386.e310 (2018).

    Article  CAS  Google Scholar 

  5. Guillen, K. P. et al. Nat. Cancer https://doi.org/10.1038/s43018-022-00337-6 (2021).

  6. Meehan, T. F. et al. Cancer Res. 77, e62–e66 (2017).

    Article  CAS  Google Scholar 

  7. Collins, A. T. & Lang, S. H. PeerJ 6, e5981 (2018).

    Article  Google Scholar 

  8. Chia, K. et al. Curr. Opin. Endocr. Metab. Res. 15, 31–36 (2020).

    Article  Google Scholar 

  9. Dustin, D., Gu, G. & Fuqua, S. A. W. Cancer 125, 3714–3728 (2019).

    Article  Google Scholar 

  10. Allen, T. M. et al. Nat. Immunol. 20, 770–774 (2019).

    Article  CAS  Google Scholar 

  11. Clohessy, J. G. & Pandolfi, P. P. Front. Oncol. 8, 340 (2018).

    Article  Google Scholar 

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Authors and Affiliations

  1. Garvan Institute of Medical Research, Sydney, New South Wales, Australia

    Neil Portman & Elgene Lim

  2. Faculty of Medicine, St. Vincent’s Clinical School, University of New South Wales, Sydney, New South Wales, Australia

    Neil Portman & Elgene Lim

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  1. Neil Portman
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  2. Elgene Lim
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Correspondence to Elgene Lim.

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The authors declare no competing interests.

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Portman, N., Lim, E. A new sophistication for breast cancer PDXs. Nat Cancer 3, 138–140 (2022). https://doi.org/10.1038/s43018-021-00328-z

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