Extended Data Fig. 8: In vitro selectivity and safety evaluation of TH9619. | Nature Cancer

Extended Data Fig. 8: In vitro selectivity and safety evaluation of TH9619.

From: Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Extended Data Fig. 8: In vitro selectivity and safety evaluation of TH9619.

(a) DSF-based selectivity screen of TH9619 12 µM against a curated library of 44 kinases, using staurosporine as a positive control. Bars represent the mean change in protein melting temperature (ΔTm) of one experiment performed in triplicate. (b) Selectivity of TH9619 10 µM against the SafetyScreen44 panel from Eurofins. Bars represent mean inhibition in percentage of one experiment performed in duplicate.

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