Table 1 Chemical structures of MTHFD2 inhibitors

From: Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

 

Structure

IC50 (nM)

EC50 (nM)

LY345899

6396

4005

TH7299

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254

1110

TH9028

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11

17

TH9619

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47

11

  1. Chemical structures of MTHFD2 inhibitors LY345899, TH7299, TH9028 and TH9619. Inhibition of MTHFD2 enzymatic activity in biochemical assays and efficacy on HL-60 cell viability are listed as IC50 and EC50 values, respectively.
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