Table 2 Biochemical inhibition of related MTHFD proteins

From: Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

 

MTHFD2 IC50 (nM)

MTHFD2L IC50 (nM)

MTHFD1-(DC) IC50 (nM)

D2/D1

LY345899

6,396

3,761

535

12

TH7299

254

126

89

3

TH9028

11

27

0.5

21

TH9619

47

47

16

3

  1. Average biochemical IC50 values for MTHFD2 inhibitors tested on MTHFD2, MTHFD2L and MTHFD1-(DC) (n ≥ 3).
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