Extended Data Fig. 7: Drug screen data sorted by HCI line. | Nature Cancer

Extended Data Fig. 7: Drug screen data sorted by HCI line.

From: A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology

Extended Data Fig. 7: Drug screen data sorted by HCI line.The alternative text for this image may have been generated using AI.

Sixteen heat maps, organized by model, illustrate individual drug responses to 45 compounds. Coloration of these heatmaps indicates CellTiter-Glo 3D cell viability assays that were normalized to day 0, ranging from 0 (black, cytotoxic) to 2 + (yellow, growth). Values at 1 are considered cytostatic. Color scaling is performed relative to each model. Drugs are sorted left to right from largest GRaoc to smallest, indicating decreasing drug efficacy in each model, respectively. Drug concentrations are micromolar units.

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