Extended Data Fig. 7: Time to adverse event analysis, related to Fig. 4. | Nature Cancer

Extended Data Fig. 7: Time to adverse event analysis, related to Fig. 4.

From: Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy

Extended Data Fig. 7: Time to adverse event analysis, related to Fig. 4.The alt text for this image may have been generated using AI.

(a) Kaplan-Meier curves indicating the time without any (left panel) or ≥ CTCAE °3 adverse event (right panel) for vaccinated (n = 64) and unvaccinated patients (n = 26) over the entire course of immune checkpoint therapy with the legend indicated below. P values (two-sided) were calculated using logrank tests (any AE: test statistic= 19.4, grade ≥3 AE: test statistic =18.7). Exact p values: 1.0475761018388364e-05 (left panel), 1.5047888131226484e-05 (right panel). (b) Kaplan-Meier curves indicating the time without any (left panel) or ≥ CTCAE °3 adverse event (right panel) for unvaccinated patients (n = 26) over the entire course of immune checkpoint therapy and for vaccinated patients before (n = 48) vaccination, up to 28 days (n = 21) after vaccination and longer than 28 days (n = 37) after vaccination. The color code, average events per day and their 95% confidence intervals (in parenthesis) are indicated in the legend below.

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