Fig. 2: Early adverse events after COVID-19 vaccination under immune-checkpoint therapy.
a, Schematic timeline depicting the start and duration of follow-up and vaccination time points of vaccinated and unvaccinated patients. b, Tree maps visualizing the proportion and the numbers of all and grade ≥3 AEs up to 4 weeks after vaccination in vaccinated patients (n = 64). In tree map for all AE: others (n = 5) include vomiting (n = 1), ileus (n = 1), upper GI bleed (n = 1), hepatic failure (n = 1) and heart failure (n = 1); pain (n = 3) includes headache (n = 2) and arthralgia (n = 1); infections (n = 3) include C. difficile infection (n = 1), E. coli sepsis (n = 1) and herpes simplex reactivation (n = 1). In tree map for grade ≥3 AEs: infections (n = 2) include C. difficile infection (n = 1) and E. coli sepsis (n = 1). c, Line-plots indicating platelet counts (n = 61, left) and CRP (n = 55, right) either after the first vaccine dose (top) or second vaccine dose (bottom). Reference ranges are indicated in pink shading. Lines are colored according to the vaccination schema used with the color code indicated below. NA, not available.
