Fig. 4: Comparable adverse events and prolonged overall survival in COVID-19-vaccinated immune-checkpoint therapy-treated patients with cancer.
a,b, Grouped bar plots indicating the frequency and error bars the 95% CI of overall AE (a) or grade ≥3 AEs (b) under ICI therapy in vaccinated (n = 64) and unvaccinated (n = 26) patients. This is proportional data and the CI is asymmetric and the center is the bar. c, Total number of hospitalizations due to irAEs and other AEs in vaccinated and unvaccinated patients (as listed in Supplementary Table 4) in vaccinated (n = 19) and unvaccinated (n = 10) patients. d, Kaplan–Meier curve indicating overall survival probability of vaccinated (n = 64) and unvaccinated (n = 26) patients under ICI therapy. P values (two-sided, test statistic 9.345) and hazard ratios (95% CI = 0.07–0.69) were calculated using a log-rank test. Grey gradient bars indicate the proportion of patients who received the first or second vaccination dose over time with the timeline indicated above and color legend indicated below. e, Forest plot indicating the results of the Cox proportional hazards model of n = 90 patients with squares indicating the log10(HR) and whiskers indicating the 95% CI. P values (two-sided) were not corrected for multiple comparisons and number of events are indicated on the left. HR, hazard ratio; CNS, central nervous system; MS, musculoskeletal.
