Extended Data Fig. 9: Single cell transcriptomic analysis of AKP Mex3a KO1 MTOs.
From: Mex3a marks drug-tolerant persister colorectal cancer cells that mediate relapse after chemotherapy
a, Cell distribution represented as UMAPs of two independent WT (WT1 and WT2) versus Mex3a KO1 AKP MTOs in untreated conditions and after treatment with FOLFIRI for 2 days or 5 days. Note that no viable cells were recovered from KO1 at 5d post-treatment. b,d,f,h,j, UMAPs showing average expression levels of the indicated signatures. Signatures are detailed in Supplementary Table 6. c,e,g,i,k, Violin plots for key marker genes of the indicated cell populations and cell states.
