Extended Data Fig. 2: Structural information. | Nature Cancer

Extended Data Fig. 2: Structural information.

From: Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling

Extended Data Fig. 2: Structural information.The alternative text for this image may have been generated using AI.

(a) Chemical structure of the HER2 TKI used as ligand in X-Ray crystallography in PDB 7PCD. (b) Ligand interaction diagram of the ligand shown in panel a with HER2. (c) Cellular IC50 data of the HER2 TKI used as ligand in the X-Ray crystal structure PDB 7PCD in comparison to BI-1622 and BI-4142. All results are quoted as the geometric mean ± SEM, pIC50 = -log IC50 (M). The number of repeats, n and the IC50, are described in parentheses. (d) X-Ray crystallography data collection, processing and refinement statistics.

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