Extended Data Fig. 9: PARPi synergizes with gemcitabine in killing high METTL16 tumor cells in vitro. | Nature Cancer

Extended Data Fig. 9: PARPi synergizes with gemcitabine in killing high METTL16 tumor cells in vitro.

From: METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma

Extended Data Fig. 9

a, Cell survival of the indicated SW1990 cells for 2-D colony formation treated with olaparib or gemcitabine or their combo. b, Relative colony number of the indicated SW1990 cells for soft agar colony formation treated with olaparib or gemcitabine or their combo. c, Cell survival of the indicated PANC-1 cells for 2-D colony formation treated with olaparib or gemcitabine or their combo. d, Relative colony number of the indicated PANC-1 cells for soft agar colony formation treated with olaparib or gemcitabine or their combo. Data are presented as mean ± SD from three independent experiments (a-d). P-values are indicated (a-d). Statistical significance was determined by two-tailed unpaired t-tests (a-d).

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