Fig. 8: Dynamics of lineage plasticity driven by ectopic JAK–STAT activation. | Nature Cancer

Fig. 8: Dynamics of lineage plasticity driven by ectopic JAK–STAT activation.

From: Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance

Fig. 8

a, UMAP plots represent the reconstructive trajectory of single cells in each of the samples. b, UMAP plots represent the reconstructive trajectory of single cells in each of the subclusters. c, UMAP plots represent the pseudotime reconstructive trajectory of single cells. Color intensity represents the pseudotime estimation of each single cell. Arrows and the dotted line represent the direction of pseudotime flow. d, UMAP plots represent the S phase score per cell in each single cell within the pseudotime reconstructive trajectory. e–h, UMAP plots represent the AR signaling and lineage scores per cell in each single cell within the pseudotime reconstructive trajectory. i, UMAP plots represent the pseudotime reconstructive trajectory of single cells of cluster 4. Color intensity represents the pseudotime estimation of each single cell. Arrows and the dotted line represent the direction of pseudotime flow. j–l, UMAP plots represent lineage scores per cell in each single cell within the pseudotime reconstructive trajectory of single cells of cluster 4. m, Schematic figure illustrating that SOX2 ectopically activates JAK–STAT signaling, which enables the transition of mCRPC to a stem-like and multilineage state. Figure created with BioRender.com. The numbers (n) of cells in each sample and cluster are the same as in Fig. 6.

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