Fig. 1: Summary of clinical outcomes.
a, Diagram of trial design. b, Summary of pathological outcomes of all evaluable patients (n = 19 patients). c, Summary of clinical outcomes of patients treated at MTD (n = 18). d, Kaplan–Meier survival curves for overall survival, PFS and local PFS survival for patients treated at MTD (n = 18 patients). e, A plot of the relationship between radiation dose and pathologic outcome at time of surgery (P = 0.05), spearman correlation coefficient 0.45, CI (−0.01909, 0.7573). 12 Gy n = 3 patients, 18 Gy n = 7 patients and 24 Gy n = 9 patients. f, Analysis of the relationship between time to surgery and pathological response (mean ± s.e.m.). Pathologic tumor response (pTR) pTR0–3 n = 6 patients and MPR/CR n = 13 patients. g, Representative images of a patient’s tumor response to treatment. h, Representative standardized uptake value (SUV) images showing a decrease in signal intensity post-treatment. A two-sided Fisher’s exact test was used in e. Statistical significance was determined by an unpaired two-sided Student’s t-test for f. Significance was concluded if P < 0.05. #For the last 9 patients the GTV was dosimetrically calculated at 24 Gy.
