Extended Data Table 1 Incidence of Treatment Related Adverse Events
AE term = >3 | % who experienced the AE in all patients | % who experienced the AE in patients received 24 Gy | % who experienced the AE in patients received 18 Gy | % of the AEs related to SBRT | % of the AEs related to Durva | % of the AEs related to Combo |
|---|---|---|---|---|---|---|
Mucositis oral | 19% | 11.1% | 11.1% | 100% | 0% | 16.7% |
Dysphagia | 9.5% | 11.1% | 0% | 100% | 0% | 0% |
Aphonia | 4.8% | 0% | 0% | 100% | 0% | 0% |
Infections and infestations - Other | 9.5% | 0% | 11.1% | 100% | 0% | 0% |
Weight loss | 9.5% | 0% | 11.1% | 100% | 0% | 0% |
Dry mouth | 4.8% | 0% | 11.1% | 100% | 0% | 0% |
Edema limbs | 4.8% | 0% | 11.1% | 0% | 100% | 0% |
Wound infection | 9.5% | 11.1% | 11.1% | 100% | 0% | 0% |
Wound dehiscence | 4.8% | 0% | 11.1% | 100% | 0% | 0% |
Oral cavity fistula | 4.8% | 0% | 11.1% | 100% | 0% | 0% |
Respiratory, thoracic and mediastinal disorders - Other | 4.8% | 0% | 11.1% | 100% | 0% | 100% |
AE term <3 | ||||||
Arthralgia | 4.8% | 0% | 11.1% | 0% | 100% | 0% |
Dysgeusia | 52.4% | 44.4% | 44.4% | 92.9% | 7.1% | 14.3% |
Mucositis oral | 66.7% | 77.8% | 44.4% | 91.3% | 8.7% | 26.1% |
Dry mouth | 28.6% | 22.2% | 22.2% | 100% | 0% | 9.1% |
Dysphagia | 23.8% | 44.4% | 0% | 100% | 16.7% | 0% |
Dermatitis radiation | 42.9% | 33.3% | 33.3% | 100% | 0% | 33.3% |
Fatigue | 57.1% | 66.7% | 33.3% | 84.6% | 69.2% | 46.2% |
Weight loss | 19% | 11.1% | 11.1% | 100% | 0% | 0% |
Edema face | 14.3% | 0% | 11.1% | 100% | 0% | 0% |
Lymphedema | 14.3% | 11.1% | 0% | 50% | 50% | 50% |
General disorders and administration site conditions - Other | 28.6% | 33.3% | 22.2% | 100% | 0% | 0% |
Cough | 14.3% | 11.1% | 11.1% | 100% | 0% | 0% |
Sore throat | 14.3% | 11.1% | 11.1% | 100% | 0% | 0% |
Gastrointestinal disorders - Other | 33.3% | 33.3% | 33.3% | 92.9% | 7.1% | 7.1% |
Nausea | 19% | 11.1% | 33.3% | 50% | 50% | 0% |
Musculoskeletal and connective tissue disorder - Other | 19% | 22.2% | 22.2% | 75% | 25% | 25% |
Trismus | 14.3% | 11.1% | 22.2% | 66.7% | 33.3% | 33.3% |
Hypothyroidism | 23.8% | 44.4% | 11.1% | 14.3% | 71.4% | 42.9% |
