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CAR T cell therapy: looking back and looking forward

Nature Cancer volume 3, pages 1418–1419 (2022)Cite this article

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Recent progress indicates a considerably improved mechanistic understanding of CAR T cell biology and delivers important insights into why some patients achieve durable remissions and others do not. In addition, although most success has been achieved in the context of CAR T cells targeted to B cell tumor antigens, namely CD19 and BCMA, we are seeing promising clinical trial outcomes for solid tumor malignancies.

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References

  1. Brentjens, R. J. et al. Sci. Transl. Med. 5, 177ra138 (2013).

    Article  Google Scholar 

  2. Locke, F. L. et al. N. Engl. J. Med. 386, 640–654 (2022).

    Article  CAS  Google Scholar 

  3. Kamdar, M. et al. Lancet 399, 2294–2308 (2022).

    Article  CAS  Google Scholar 

  4. Jain, M. D. Mol. Ther. 30, 14–16 (2022).

    Article  CAS  Google Scholar 

  5. Melenhorst, J. J. et al. Nature 602, 503–509 (2022).

    Article  CAS  Google Scholar 

  6. Haradhvala, N. J. et al. Nat. Med. 28, 1848–1859 (2022).

    Article  CAS  Google Scholar 

  7. Good, Z. et al. Nat. Med. 28, 1860–1871 (2022).

    Article  CAS  Google Scholar 

  8. Lee, J. C. et al. Cancer Res. 71, 2871–2881 (2011).

    Article  CAS  Google Scholar 

  9. Scholler, N. et al. Nat. Med. 28, 1872–1882 (2022).

    Article  CAS  Google Scholar 

  10. Jain, M. D. et al. Blood 137, 2621–2633 (2021).

    Article  CAS  Google Scholar 

  11. Faramand, R. et al. Clin. Cancer Res. 26, 4823–4831 (2020).

    Article  CAS  Google Scholar 

  12. Jain, M. D. et al. Blood 140, 491–503 (2022).

    Article  CAS  Google Scholar 

  13. Mailankody, S. et al. N. Engl. J. Med. 387, 1196–1206 (2022).

  14. Qi, C. et al. Nat. Med. 28, 1189–1198 (2022).

    Article  CAS  Google Scholar 

  15. Narayan, V. et al. Nat. Med. 28, 724–734 (2022).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Medicine, Roswell Park Cancer Center, Buffalo, NY, USA

    Marco L. Davila & Renier J. Brentjens

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  1. Marco L. Davila
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  2. Renier J. Brentjens
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Correspondence to Renier J. Brentjens.

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Competing interests

M.L.D. has equity or options to purchase equity in Bellicum, Precision Biosciences and Adicet. M.L.D. has received licensing revenue from CRISPR and Atara Biotherapeutics. M.L.D. has received fees from Adicet, Syncopation, Synthekine and Bellicum. R.J.B. has licensed intellectual property to and collect royalties from Bristol Myers Squibb (BMS), Caribou and Sanofi. R.J.B. received research funding from BMS. R.J.B. is a consultant to BMS, Atara Biotherapeutics, Coimmune and Triumvira, and was a consultant for Gracell Biotechnologies, but ended employment in the past 24 months. R.J.B. is a member of the scientific advisory board for CoImmune and Triumvira.

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Davila, M.L., Brentjens, R.J. CAR T cell therapy: looking back and looking forward. Nat Cancer 3, 1418–1419 (2022). https://doi.org/10.1038/s43018-022-00484-w

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