Extended Data Fig. 8: DUSP6 mediates response to JAK2 inhibitors.
From: DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression
a) Correlation of DUSP6 expression and fedratinib IC50 in 18 AML cell lines. DUSP6 expression obtained from the CCLE database and fedratinib IC50 obtained from the GDSC1 collection. b) Cell viability assay of HEL parental or HEL Fed-P cells treated with BCI at the indicated doses. Cells were treated for 72 hours and viability was normalized to the control treatment from each group. n = 6 independently treated cell cultures pooled from two independent experiments at each drug dose. Mean and standard deviation presented. c) Cell viability assay of HEL cells treated with BCI, fedratinib, or combination. Cells were treated for 72 hours at the indicated drug doses and viability was normalized to the control treatment. n = 6 independently treated cell cultures pooled from two independent experiments at each drug dose. Mean and standard deviation presented.
