Extended Data Fig. 9: Metastatic tumor-associated DNA hypomethylation at distal enhancer elements. | Nature Cancer

Extended Data Fig. 9: Metastatic tumor-associated DNA hypomethylation at distal enhancer elements.

From: Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

Extended Data Fig. 9

a-d. Analysis of putative enhancer target genes involved in the regulation of cell adhesion. For each gene, a comparison of distal element DNA methylation between 29 primary and 72 metastatic tumors is shown on the left, and putative target gene expression between methylated (β value ≥ 0.4) vs. unmethylated (β value of < 0.4) tumors is shown on the right. The p values were calculated using Welch’s two-sample t-test, two-sided. LumA, Luminal A; LumB, Luminal B; Claudin, Claudin-low.

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