Fig. 3: Individuals with multiple metastases were examined for immune features in the AURORA–RAP combined cohort. | Nature Cancer

Fig. 3: Individuals with multiple metastases were examined for immune features in the AURORA–RAP combined cohort.

From: Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

Fig. 3

a, Gene expression signature scores of GP2-immune-metagene are shown according to individual specimens from participants with at least two metastases analyzed by RNAseq data (n = 14 individuals). The star indicates liver specimens with the lowest expression of signature. b, Expression changes between paired primary tumors and liver (36 pairs), brain (15 pairs), lung (21 pairs) or ‘rest’ (110 pairs) metastases of the GP2-immune-metagene signature (individuals with more than one metastasis in the same organ were averaged). Comparisons between two paired groups were performed by a two-sided paired samples Wilcoxon test. Statistically significant values are highlighted in red. All box and whisker plots display the median value on each bar, showing the lower and upper quartile range of the data (Q1 to Q3). The whiskers represent the lines from the minimum value to Q1 and Q3 to the maximum value; LumA, Luminal A, ; LumB, Luminal B; Brt, breast; Adr, adrenal; Liv, liver; Dip, diaphragm; Per, peritoneum; Rct, rectum, Skn, skin; Stm, stomach; Thy, thyroid; SoftT, soft tissue; LN, lymph node; Ple, pleura; Lun, lung; Brn, brain; Bon, bone; Kid, kidney; Che, chest; Spl, spleen; Mes, mesentery; Pan, pancreas; AUR, AURORA.

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