Extended Data Fig. 2: Prominent infiltration of myeloid immunosuppressive cells in human PDAC tumors. | Nature Cancer

Extended Data Fig. 2: Prominent infiltration of myeloid immunosuppressive cells in human PDAC tumors.

From: Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer

Extended Data Fig. 2

A. Representative images of normal pancreas and human PDAC tumors with indicated staining. Scale bars: 100 µm. Red arrow indicates positively stained cells. B. Clustering of human TCGA PDAC samples (n = 178 patients) into MDSC-high, MDSC-low and MDSC-medium groups using a 39-gene MDSC signature13. C. CIBERSORTx quantification of monocyte/macrophage subset fraction in human PDAC samples; TCGA (n = 178 patients) and ICGC-AU (n = 92 patients). D. Representative images of normal pancreas and human PDAC tumors with indicated staining. Scale bars: 100 µm. Red arrow indicates positively stained cells. E. Kaplan-Meier plot depicting overall survival of TCGA PDAC patients (n = 178 patients) grouped by the gene expression signatures of C1q+ TAM (top) and Spp1+ TAM (bottom).

Source data

Back to article page