Extended Data Fig. 3: Heterogeneity of myeloid cells in iKRAS PDAC tumors identified by single cell gene expression profiling. | Nature Cancer

Extended Data Fig. 3: Heterogeneity of myeloid cells in iKRAS PDAC tumors identified by single cell gene expression profiling.

From: Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer

Extended Data Fig. 3

A. UMAP of all live CD45+ cells used for scRNA-seq analysis of untreated iKRAS tumors (n = 4,080 cells). B. Representative genes and functional markers used for identification of immune cell clusters. C. Heatmap of six immune cell clusters with unique signature genes. D. Representative genes and functional markers used for identification of myeloid cell clusters. E. Heatmap of myeloid cell clusters with unique signature genes. F. Representative genes and functional markers used for identification of dendritic cell clusters.

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