Extended Data Fig. 10: Physiological relevance of p53 R175H mutation in cancer patients. | Nature Cancer

Extended Data Fig. 10: Physiological relevance of p53 R175H mutation in cancer patients.

From: Specific regulation of BACH1 by the hotspot mutant p53R175H reveals a distinct gain-of-function mechanism

Extended Data Fig. 10: Physiological relevance of p53 R175H mutation in cancer patients.The alternative text for this image may have been generated using AI.

a, b. Violin plots of SLC7A11/ CEMIP expression in cancer patients with distinct p53 mutation. Analyses are based on data from cBioPortal Pan-cancer studies and specific cancer types studies (271 pan-cancer and specific cancer studies were included). a, SLC7A11; b, CEMIP. P values were calculated by two-tailed Student’s t-test. n numbers are shown on the panels. P values in a (from left to right): 0.000039; 0.8038; 0.6746; 0.9791. P values in b (from left to right): 0.0092; 0.7587; 0.916; 0.7466. c-i, Correlation between BACH1 expression level and patients’ overall survival in different p53 mutation status. c, p53R175H; d, p53R248Q/W; e, p53R273H; f, p53G245S; g, p53R249S; h, p53R282W; i, p53 wild-type. Distinct p53 mutation patients’ BACH1 expression and survival data were obtained from TCGA pan-cancer database (xenabrower.net). P values of survival curves were calculated by Log-rank (Mantel-Cox) test. n numbers are shown on the panels. P values: 0.0233 (c); 0.4013 (d); 0.9842 (e); 0.6665 (f); 0.6148 (g); 0.8513 (h); 0.0195 (i).

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