Extended Data Fig. 1: Binding affinity of HER2-XPAT protein and its partially and fully unmasked metabolites to cynomolgus monkey HER2 and CD3. | Nature Cancer

Extended Data Fig. 1: Binding affinity of HER2-XPAT protein and its partially and fully unmasked metabolites to cynomolgus monkey HER2 and CD3.

From: Precision-activated T-cell engagers targeting HER2 or EGFR and CD3 mitigate on-target, off-tumor toxicity for immunotherapy in solid tumors

Extended Data Fig. 1

Binding was assessed in vitro at 37°C by surface plasmon resonance. Data are KD (n=8 to 12 technical replicates of a single experiment; individual data points are displayed on the graph). Surface plasmon resonance sensorgrams for these data are provided in Supplementary Figs. 11–18. HER2, human epidermal growth factor receptor 2; uTCE, unmasked HER2 T-cell engager; XPAT proteins, TCEs fused to XTEN polypeptides.

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