Extended Data Fig. 9: Pattern of essentiality for genes downstream of IRF4 or IKZF1/IKZF3.
CERES scores for genes previously defined as a, IRF4 target genes in MM cells5 or b, genes that are downregulated by loss-of-function of IKZF1 or IKZF3 (GSE113031) are depicted in a heatmap format (similar to Fig. 1) and in clusters of genes which (i) can be considered ‘core essential’ genes (for example, CERES < -0.4 in ≥90% of cell lines across cancers); (ii) meet all criteria for MM-preferential dependencies vs. other genes that have CERES scores < -0.4 in (iii) >50% of MM cell lines tested, (iv) 30-50% of MM cell lines tested; (v) <30% of MM cell lines tested; or (vi) none of the MM cell lines tested.
