Extended Data Fig. 3: HNRNPA2B1 binds and stabilizes the long NQO1 isoform and increases NQO1 expression. | Nature Cancer

Extended Data Fig. 3: HNRNPA2B1 binds and stabilizes the long NQO1 isoform and increases NQO1 expression.

From: A sense-antisense RNA interaction promotes breast cancer metastasis via regulation of NQO1 expression

Extended Data Fig. 3: HNRNPA2B1 binds and stabilizes the long NQO1 isoform and increases NQO1 expression.

(a) DeepBind sequence analysis of NQO1 3’UTR distal region complementary to NQO1-AS. Consensus motifs for HNRNPH2, SRSF10, and HNRNPA2B1 are highlighted. (b) Spearman correlation between NQO1 expression and HNRNPA2B1 expression in METABRIC dataset. N = 1904 patients. (c) Spearman correlation between NQO1 expression (left), NQO1 stability (right) and HNRNPA2B1 expression in TCGA-BRCA dataset. N = 1100 patients. (d) Spearman correlation between NQO1-AS expression and HNRNPA2B1 expression in TCGA-BRCA dataset. N = 1060 patients.

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