Therapeutic products containing CD8+ and CD4+ T cells expressing CARs are effective at inducing remission in patients with cancer. How CD4+ CAR T cells contribute to the anti-tumor response has not been well established. A study uses syngeneic models and in vivo imaging to glean mechanistic insights into how CD4+ T cells target tumors.
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Kohler, M.E., Fry, T.J. CD4+ CAR T cells — more than helpers. Nat Cancer 4, 928–929 (2023). https://doi.org/10.1038/s43018-023-00567-2
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DOI: https://doi.org/10.1038/s43018-023-00567-2
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