Extended Data Fig. 2: TEAD SMIs selectively modulate YAP/TAZ target genes.
a) Heatmap showing expression of the YAP/TAZ target genes measured by mRNA-sequencing in OVCAR-8 and HCC1576 cells treated with the indicated compounds (n = 3 independently treated cell cultures). (b) Box plot showing aggregated expression changes of the YAP/TAZ target genes in HCC1576 cells treated with the indicated compounds (n = 3 indepedently treated cell culture). Data are presented as median +/− 25%. The lower and upper whiskers extend from the hinge to the smallest or largest values. (c) Downregulation of YAP/TAZ target genes in a time- and concentration-dependent manner in YAP-amplified OVCAR-8 cells (left), but not in control NF2 wildtype, YAP/TAZ negative SK-N-FI cells (right). Error bars represent SD (n = 3 independently treated cell cultures).
