Extended Data Fig. 8: Basic information of stromal cell clusters and gene expressions of mesothelial cells in ascites. | Nature Cancer

Extended Data Fig. 8: Basic information of stromal cell clusters and gene expressions of mesothelial cells in ascites.

From: Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer

Extended Data Fig. 8: Basic information of stromal cell clusters and gene expressions of mesothelial cells in ascites.

a, UMAP plots showing expression levels of cluster-specific marker genes in stromal cells. b-c, Tissue distribution of each stromal cell cluster, colored by tissues (b) and clusters (c). Stromal cells were un-detectable in blood. d, Violin plots showing the expression levels of adhesion-associated genes in 3 mesothelial cell clusters derived from tumor sites. Totally n = 14 HGSOC tumor samples, including n = 10 primary tumor and n = 4 omentum metastasis samples were analyzed. e, Heatmap showing the expression levels of chemokines and HLA-related genes in 4 stromal cell clusters detected in ascites. Rows represent clusters and columns represent genes. All n = 8 ascites samples from HGSOC patients were used for analysis. f, UMAP plots showing the similarity of ascites-derived cancer-associated fibroblasts (CAF) reported by Aviv (left) and stromal cells enriched in ascites in our dataset (right). For a-c, all n = 31 HGSOC samples were used for analysis.

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