Extended Data Fig. 9: Distribution and gene expressions of endothelial cells as well as association of E02, E06 clusters with HGSOC prognosis. | Nature Cancer

Extended Data Fig. 9: Distribution and gene expressions of endothelial cells as well as association of E02, E06 clusters with HGSOC prognosis.

From: Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer

Extended Data Fig. 9: Distribution and gene expressions of endothelial cells as well as association of E02, E06 clusters with HGSOC prognosis.

a, Tissue distribution of each endothelial cell cluster identified in HGSOC patients, colored by different tissues (upper) and clusters (lower). b, Heatmap showing the expression levels of indicated marker genes of tip-like endothelial cell in 8 endothelial cell clusters. Rows represent clusters and columns represent genes. c, Heatmap showing the expression levels of genes involved in MHC-II antigen presentation in 8 endothelial cell clusters. Rows represent clusters and columns represent genes. d, The Kaplan–Meier overall survival curves of HGSOC patients grouped by the gene signature expression of VCAM1+ ENDO cells (E06). TCGA OV data. HR, hazard ratio. Multivariate Cox regression. e, The Kaplan–Meier overall survival curves of HGSOC patients grouped by the gene signature expression of IL13RA1+ ENDO cells (E02). TCGA OV data. HR, hazard ratio. Multivariate Cox regression. f, The Kaplan–Meier overall survival curves of HGSOC patients grouped by the gene signature expression of VCAM1+ ENDO cells (E06). Microarray GSE9891 and GSE19829-GPL8300. HR, hazard ratio. Multivariate Cox regression. Statistical significance (P value) was determined by Kaplan–Meier survival curves and log-rank test (d-f). For a-c, all n = 31 HGSOC samples were used for analysis.

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