Extended Data Fig. 1: Basic information of 14 major clusters in OC.
a, UMAP plots showing 14 clusters of other OC subtypes identified by integrated analysis. Data were summarized from n = 4 patients of other ovarian tumor types. OCCC1: Ovarian clear cell carcinomas, ECO1: Endometrioid carcinoma of the ovary, UOC1: Undifferentiated ovarian cancer, C1: ovarian carcinosarcoma. Each dot corresponds to a single cell, colored by clusters. b, UMAP plots showing expression levels of highly expressed genes (including cluster-specific marker genes) in 14 major cell clusters using data of HGSOC patients. c, Heat map depicting selected activated pathways across major clusters using data of HGSOC patients. Rows represent pathways and columns represent clusters. Pathways, GO, adjusted P value by Benjamini-Hochberg (BH) procedure < 0.05. d, Tissue distribution of detected cells in each n = 10 HGSOC patient, colored by tissues. e, Patient distribution (upper) and tissue distribution (lower) of each major cluster detected in n = 10 HGSOC patients, colored by clusters. For b-e, totally n = 31 HGSOC samples including n = 5 peripheral blood, n = 4 pelvic lymph node (PLN), n = 10 primary ovarian tumor (Pri.OT), n = 4 matched omentum metastatic tumor (Met.Ome), and n = 8 ascites samples were used for analysis.
