Extended Data Fig. 7: The clonal/subclonal architecture of mutp53-stabilizing precancerous and cancerous cells. | Nature Cancer

Extended Data Fig. 7: The clonal/subclonal architecture of mutp53-stabilizing precancerous and cancerous cells.

From: Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues

Extended Data Fig. 7: The clonal/subclonal architecture of mutp53-stabilizing precancerous and cancerous cells.The alternative text for this image may have been generated using AI.

(a, b, c) InferCNV analyses on single-cells from 4 M (a, n = 3251 cells), 5 M (b, n = 5105 cells), and End2 (c, n = 7292 cells), combining mCherry+ and mCherry− cells from the same mice and using cells from WT as a reference. Yellow and green lines on the left distinguish mCherry+ and mCherry−cells. Blue, chromosome loss. Red, chromosome gain. Dashed boxes mark different clones or subclones. (a’, b’, c’) Reconstructed clonal evolutionary trees for clones/subclones marked in (a, b, c) based on the most parsimonious order of CNV occurrences. For cells at each arm of clonal evolutionary trees, their total number, mCherry+ cell percentage (red%), shared CNVs (Amp, amplification; Del, deletion/loss), and cell type composition (stacked bars) are indicated.

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