Extended Data Fig. 8: Deregulated pathways in precancerous ISPs. | Nature Cancer

Extended Data Fig. 8: Deregulated pathways in precancerous ISPs.

From: Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues

Extended Data Fig. 8

(a) Venn charts showing the overlap of genes upregulated and downregulated in p53mCherry+ ISPs cells compared with paired mCherry− ISPs without overt CNVs in 3M_C1 and 4M_C1 clones. (b) GSEA analyses of shared differentially expressed genes in (a). Top tumor-related pathways and KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN pathway (genes down-regulated upon aminopeptidase inhibitor Tosedostat treatment) are shown (P adj. < 0.01). P values and NES scores were calculated using GSEA algorithm (Methods).

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