Extended Data Fig. 3: Endstage primary tumors and metastasis in p53-mutant mice. | Nature Cancer

Extended Data Fig. 3: Endstage primary tumors and metastasis in p53-mutant mice.

From: Protein-level mutant p53 reporters identify druggable rare precancerous clones in noncancerous tissues

Extended Data Fig. 3

(a) Whole-mount images of thymic lymphoma, carcinoma, and sarcoma from PCC mice. (b) Whole-mount images of spleen and liver metastasis in PCL and PLL mice. (c) Representative H&E staining of sarcoma (n = 4 tumors) metastasized to the spleen or liver, and carcinoma (n = 3 tumors) metastasized to the liver in PCL and PLL mice. (d) An example H&E staining of multi-focal malignant glioma in PCN and PCLN mice. (e) Representative FACS analyses of mCherry on thymic lymphoma, carcinoma, and sarcoma from PCC mice, using thymuses from age-matched wildtype mice as controls. The boxed area shows the gating strategy and the percentage of p53mCherry+ cells. Results are representative of 3 samples per tumor type.

Back to article page