Extended Data Fig. 3: WNTinib reduces EZH2 phosphorylation to drive the suppression of essential gene networks in CTNNB1-mutated HCC. | Nature Cancer

Extended Data Fig. 3: WNTinib reduces EZH2 phosphorylation to drive the suppression of essential gene networks in CTNNB1-mutated HCC.

From: WNTinib is a multi-kinase inhibitor with specificity against β-catenin mutant hepatocellular carcinoma

Extended Data Fig. 3

a-b, PCA of transcriptomics (a) displaying MYC-CTNNB1 tumor organoids treated or not with WNTinib for 1 hour, 24 hours, or 7 days, as related to Fig. 2b. N = 2 independent experiments. b, Volcano plots depicting transcriptomic changes elicited by WNTinib as related to panel a. Inset: pathway enrichment terms associated with significantly regulated transcripts. c-d, PCA of transcriptomics (c) displaying MYC-Tp53 tumor organoids treated or not with WNTinib for 1 hour, 24 hours, or 7 days, as related to Fig. 2b. N = 2 independent experiments. d, Volcano plots depicting transcriptomic changes elicited by WNTinib as related to panel c. Inset: pathway enrichment terms associated with significantly regulated transcripts. For panels b, d – differential events were identified using two-sided Wald tests with Benjamini-Hochberg multiple testing corrections. Extended data associated with Fig. 2.

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