Extended Data Fig. 7: Kdm6b deletion alters the chromatin landscape of intratumoral myeloid cells. | Nature Cancer

Extended Data Fig. 7: Kdm6b deletion alters the chromatin landscape of intratumoral myeloid cells.

From: Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade

Extended Data Fig. 7: Kdm6b deletion alters the chromatin landscape of intratumoral myeloid cells.The alternative text for this image may have been generated using AI.

a, UMAP demonstrating the CTL and Treg clusters in the GBM (GL261) TME of control and LysMcreKDM6Bfl/fl mice determined by scATAC seq (as shown in Fig. 5a, b). Bar graphs depicting the frequencies and ratio of intratumoral CTLs and Tregs in control and LysMcreKDM6Bfl/fl mice as determined from scATAC seq. b, Coverage plots depicting the chromatin accessibility of the indicated genes in the CTL and Treg clusters. c, Heatmap showing the expression of genes of interest in the indicated myeloid cell clusters (shown in Fig. 5d). d,e, Coverage plots depicting accessibility of indicated chromatin regions (peaks) in genes of interest.

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