Extended Data Fig. 9: Elucidating the effects of Chat on inhibitory immunoreceptor expression by T cells in HCC. | Nature Cancer

Extended Data Fig. 9: Elucidating the effects of Chat on inhibitory immunoreceptor expression by T cells in HCC.

From: Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma

Extended Data Fig. 9: Elucidating the effects of Chat on inhibitory immunoreceptor expression by T cells in HCC.The alternative text for this image may have been generated using AI.

a-f Expression levels of the immune inhibitory receptors PD-1, Tim-3 and Lag-3 in CD4+ T cells (a-c), and in CD8+ T cells (d-f), from HCC-bearing livers of Chatfl/fl and Chatfl/fl;CD4-Cre mice on day 35 of HCC induction. Each dot represents an individual mouse (n=11 mice in Chatfl/fl and n=12 mice in Chatfl/fl;CD4-Cre). Data are the mean ± SEM. P values were determined by unpaired, two-tailed t-test. Related to Fig. 7.

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