Extended Data Fig. 10: Structural variant distribution and candidate driver gene expression in CedBTN.
From: Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule
a, Circos plots representing the distribution of BTN-specific structural variants within the predivergence (ancestral) and postdivergence phylogenetic variant sets in CedBTN1 and CedBTN2. Deletions and duplications of size <10 kb are omitted for interpretability. b, Distributions of structural variant frequency, density and type composition (top to bottom) per reference chromosome, for variants identified in CedBTN1 (left) and CedBTN2 (right). c, Expression of genes with potential early driver CN alterations in CedBTN. For each of the four genes with potential early driver CN alterations, normalized gene expression counts are shown for normal tissue samples (n = 28), CedBTN1 samples (n = 6) and CedBTN2 samples (n = 2). Each dot represents one sample, and gray lines denote the median expression for each group. Normal hemolymph samples (n = 4) are marked in light blue. Adjusted p-values are shown for comparisons between normal tissues and each CedBTN lineage, obtained via differential expression analysis (two-sided Wald tests with Benjamini–Hochberg correction). Seven normal tissue samples presented null MGMT expression: ENCE17/3572B (gill), EYCE21/503H (hemolymph), EYCE21/507B (gill), EYCE21/507G (gonad), EYCE21/514H (hemolymph), ENCE21/2M (mantle), ENCE21/5F (foot). Normalized gene count values are comparable across samples for the same gene, but are not comparable across genes.
