Extended Data Fig. 1: Frequency and progression stages of disseminated neoplasia in C. edule.
From: Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule
a, Numbers of individuals diagnosed with each stage of cockle DN (early or N1, intermediate or N2, and late or N3) in each country where DN was detected. b–m, Micrographs of histological sections of cockle DN at different stages of progression: early stage, N1 (b, e, h, k); intermediate stage, N2 (c, f, i, l); and late stage, N3 (d, g, j, m). Histological sections show the gills (b–d), digestive gland (e–g), gonad (h–j) and foot (k–m). n–p, Hemolymph cell monolayers of cockle DN at stages N1 (n), N2 (o) and N3 (p). Arrows indicate neoplastic cells; asterisks mark mitotic phases of neoplastic cells.
