Extended Data Fig. 8: Significantly different ex vivo drug responses between responders and non-responders.
(a) Boxplots showing viability (AUC in single-drug conditions and VUC in daunorubicin + cytarabine combination) after ex vivo drug treatment for drugs with significantly different responses in responders and non-responders. P-values from two-sided Students t-tests. Responder: n = 47, Non-responder: n = 48. Center, hinges and whiskers of the boxplots signify median, quartiles and 1.5x IQR, respectively. (b) Dose response curves for corresponding single drug conditions. Dose-response curves were built by fitting a 5-parameter logistic model for each clinical response group using ex vivo viability measurements across five drug concentrations. Individual patient observations are displayed by circles. Error bars represent mean and 95% CI. Responder: n = 47, Non-responder: n = 48.
