Extended Data Fig. 3: Landscape of the immune environment according to time point and response group. | Nature Cancer

Extended Data Fig. 3: Landscape of the immune environment according to time point and response group.

From: Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens

Extended Data Fig. 3

Projected cells on reference UMAP by time-point and response. Each UMAP has a comparable number of cells to the normal bone marrow reference. T1=time-point 1, T2=timepoint 2, n=number of cells, ref_UMAP= reference UMAP, WNN_UMAP= Weighted Nearest Neighbor Analysis derived UMAP, Mono= monocytes, NK=natural killer, DC=dendritic-cells. Visual differences can be appreciated such as the significant reduction in B and T-cell at T2 in patients who achieve MRD-negativity. n=represent number of cells.

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