Extended Data Fig. 10: Sirpa-/- myeloid cells enhance the recruitment of T lymphocytes. | Nature Cancer

Extended Data Fig. 10: Sirpa-/- myeloid cells enhance the recruitment of T lymphocytes.

From: Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47

Extended Data Fig. 10

a. The L–R pairs in secreting signaling from mMDSC, TAM and gMDSC (sender) to other cell types (receiver) in AOM/DSS-treated WT mice and Sirpa-/- mice calculated by CellChat. Line width indicates signal strength and line color is the same as signaling sender. b. The dominant sender and receiver cell types of chemokine signaling pathways (CCL and CXCL pathways) calculated by CellChat. Count represents the number of L–R pairs. c. The gene expression levels of various chemokines in TAMs of MC38 tumors from WT mice (n = 4 samples) or Sirpa-/- mice (n = 5 samples). d. Boxplot showing the SIRPA expression on macrophages in recurrent GBM patients pre- and post-neoadjuvant PD-1 blockade treatment. All samples were isolated from independent mice.The two-sided unpaired t-test was used to calculate P value. Result (c) is from one independent experiment. Error bars show mean ± s.e.m. Unpaired Student’s two-tailed t-test was used for c.

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