Extended Data Fig. 8: Parsimonious migration models depicting intersample clonal seeding.

Plausible clonal dissemination patterns between samples of all patients included in Fig. 6 or patients with multiple metastatic samples (total patient n = 14). Pie plot proportion is not representative of clonal proportion within samples. Clinically-relevant somatic alterations, whole-genome duplication status, and select clinical characteristics are annotated. Unlabeled nodes represent hypothetical monoclonal samples (that is not directly observed/sequenced) to assist with interpretation (via showing stepwise clonal evolution where possible). ADT: androgen-deprivation therapy, del: copy number deletion, mut: mutation (single-nucleotide substitution / small insertion or deletion), MLN: metastatic lymph node, PB: prostate biopsy, RP: radical prostatectomy.