Extended Data Fig. 9: Concordance between plasma ctDNA and same-patient tumor tissue samples. | Nature Cancer

Extended Data Fig. 9: Concordance between plasma ctDNA and same-patient tumor tissue samples.

From: Multiregion sampling of de novo metastatic prostate cancer reveals complex polyclonality and augments clinical genotyping

Extended Data Fig. 9

a. Oncoprint of all same-patient formalin-fixed paraffin-embedded (FFPE) samples and the cell-free DNA (cfDNA) sample with the highest ctDNA fraction collected prior to androgen-deprivation therapy (ADT) initiation, for the 10 patients with detected ctDNA pre-ADT. Asterisks indicate the patient who received ADT prior to radical prostatectomy. Total sample n = 156 (146 tissue; 10 cfDNA). b. ctDNA fraction and prostate-specific antigen (PSA) levels (ng/mL) of 3 patients with pre- and post-radical prostatectomy cfDNA collections. c. Composite oncoprint of all same-patient FFPE samples and the cfDNA sample with the highest ctDNA sample fraction collected after progression to metastatic castration-resistant prostate cancer (mCRPC), for 8 patients. Asterisks indicate patients who received androgen-deprivation theory (ADT) prior to radical prostatectomy. Total sample n = 129 (121 tissue; 9 cfDNA). CNV: copy number variant, LR: log ratio.

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