Extended Data Fig. 3: Nab-paclitaxel increases gemcitabine sensitivity in PDAC cells lacking APOBEC3C or APOBEC3D.
a, Quantification of multinucleated HPAF-II cells following 50 or 100 nM nab-paclitaxel treatment for 72 hours. A minimum of 1691 cells were quantified for untreated (n = 1691) and 50 nM (n = 1709) and 100 nM (n = 1734) nab-paclitaxel conditions, with greater than 411 cells quantified for each sample per experiment (n = 3 independent drug treatments and multinucleated cell counts). Statistical support was determined using two-tailed unpaired t-tests. Horizontal bars indicate the means. b, Representative micrographs of HPAF-II cells treated with 0, 50, or 100 nM nab-paclitaxel in the experiments from panel a, with multinucleated cells labeled with arrowheads. Scale bar, 10 µm. a, b, Relate to Fig. 2k.
