Extended Data Fig. 8: Flow characterization of post-rapid expansion protocol patient-derived tumour infiltrating lymphocytes.
From: Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies
a, Flow profile of transduced TIL transduced for 80BB (left) and LNGFR (right). b, c, d, Flow profile of post-rapid expansion protocol TILLNGFR (blue) and TIL80BB (red) cells stained for 80BB ligands CD28 and CTLA4 (b), differentiation markers CCR7, CD62L, CD45Ra (c), exhaustion markers PD-1, Lag3, Tim3 (d). e, Fraction of cells killed after 18 hrs of co-culture of transduced TIL and autologous tumour cells. n = 3 independent co-cultures from cells expanded from 1 patient-derived tumour sample. Data are mean ± sem.
