Extended Data Fig. 2: UMAP projections and Suerat clustering of 19-HIT and 19-HIT80BB cells.
From: Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies
a, UMAP projection of 2591 cells isolated from bone marrow of NALM6 bearing mice nine days post 19-HIT or 19-HIT80BB treatment. Cells are coloured based on Suerat assigned cluster identities. Clusters 0, 1, 2, 3 and 5 are composed of 19-HIT80BB cells. Cluster 4 is predominantly composed of 19-HIT cells. b, Feature and violin plots of CD8A (left), CD4 (right) transcripts. c, Dot plot of top 10 differentially enriched genes in each cluster. Colour of dot indicates expression level, and size of dot indicated percentage of cells expressing marker. d, Feature and violin plots of MKI67 (left), IL7R (right). For violin plots, cells are plotted segregated by cluster and by treatment type.
