Extended Data Fig. 3: Immune correlates between TMB-high and TMB-low cancers using the earliest cutoff at which ICIs are predictive. | Nature Cancer

Extended Data Fig. 3: Immune correlates between TMB-high and TMB-low cancers using the earliest cutoff at which ICIs are predictive.

From: Tissue-specific thresholds of mutation burden associated with anti-PD-1/L1 therapy benefit and prognosis in microsatellite-stable cancers

Extended Data Fig. 3

PD-L1 positive cell frequency, T-cell inflammatory score, and CD8 + T cell frequency are compared between TMB-high cancers and TMB-low cancers using the earliest cutoff at which ICIs are associated with OS benefit. Biomarkers enriched in TMB-high and TMB-low cancers using a false discovery rate of 0.05 are highlighted.

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