Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Briefing
  • Published:

Defining the transcriptional lineages of breast cancer subtypes

In this work, we demonstrate the transcriptional networks that link breast cancer subtypes and their cells of origin, and how transcriptional signatures differ between benign cells and cancer.

This is a preview of subscription content, access via your institution

Access options

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Transcriptional and chromatin links between breast cancer subtypes and benign duct cell types.

References

  1. The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61–70 (2012). This seminal paper reports key genomic and proteomic patterns associated with subtypes of breast cancer.

    Article  PubMed Central  Google Scholar 

  2. Keller, P. J. et al. Defining the cellular precursors to human breast cancer. Proc. Natl Acad. Sci. USA. 109, 2772–2777 (2011). A review article that discusses evidence for the distinct cells of origin that give rise to breast cancer subtypes.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Wu, S. et al. A single-cell and spatially resolved atlas of human breast cancers. Nat. Genet. 53, 1334–1347 (2021). A key paper that demonstrates the use of single-cell multiomic protocols in breast cancer.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Black, S. et al. CODEX multiplexed tissue imaging with DNA-conjugated antibodies. Nat. Protoc. 16, 3802–3835 (2021). This protocol paper details the method of multiplex immunofluorescence imaging with the CODEX platform.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Iglesia, M. D. et al. Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages. Nat. Cancer https://doi.org/10.1038/s43018-024-00773-6 (2024).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Defining the transcriptional lineages of breast cancer subtypes. Nat Cancer 5, 1605–1606 (2024). https://doi.org/10.1038/s43018-024-00774-5

Download citation

  • Published:

  • Version of record:

  • Issue date:

  • DOI: https://doi.org/10.1038/s43018-024-00774-5

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer