In this work, we demonstrate the transcriptional networks that link breast cancer subtypes and their cells of origin, and how transcriptional signatures differ between benign cells and cancer.
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References
The Cancer Genome Atlas Network. Comprehensive molecular portraits of human breast tumours. Nature 490, 61–70 (2012). This seminal paper reports key genomic and proteomic patterns associated with subtypes of breast cancer.
Keller, P. J. et al. Defining the cellular precursors to human breast cancer. Proc. Natl Acad. Sci. USA. 109, 2772–2777 (2011). A review article that discusses evidence for the distinct cells of origin that give rise to breast cancer subtypes.
Wu, S. et al. A single-cell and spatially resolved atlas of human breast cancers. Nat. Genet. 53, 1334–1347 (2021). A key paper that demonstrates the use of single-cell multiomic protocols in breast cancer.
Black, S. et al. CODEX multiplexed tissue imaging with DNA-conjugated antibodies. Nat. Protoc. 16, 3802–3835 (2021). This protocol paper details the method of multiplex immunofluorescence imaging with the CODEX platform.
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This is a summary of: Iglesia, M. D. et al. Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages. Nat. Cancer https://doi.org/10.1038/s43018-024-00773-6 (2024).
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Defining the transcriptional lineages of breast cancer subtypes. Nat Cancer 5, 1605–1606 (2024). https://doi.org/10.1038/s43018-024-00774-5
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DOI: https://doi.org/10.1038/s43018-024-00774-5