Extended Data Fig. 7 | Nature Cancer

Extended Data Fig. 7

From: Targeting a lineage-specific PI3Kɣ–Akt signaling module in acute myeloid leukemia using a heterobifunctional degrader molecule

Extended Data Fig. 7

a. Synthetic scheme for the synthesis of non-PIK3CG-targeting control compound for ARM165, ARM204. Reagents and conditions are provided below the synthesis scheme. b. Representative growth inhibition curves with IC50s and AUCs (n = 7, mean ± SD), corresponding to the Fig. 5b for AML and non-AML cells treated with increasing doses of ARM204, AZ2, and ARM165.

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