Extended Data Fig. 4: Tissue preference of major cell types.

(a) Hematoxylin-eosin staining and IgG, IgA genes expression in spatial transcriptomic spots of tumors and adjacent normal regions. The results were replicated in two patients. (b) Box plots (top and bottom quartiles with horizontal lines at the median) showing the relative proportion of certain cell types in the validation cohort. Each dot indicates a sample, n = 17 (paracancerous) and 98 (tumor). Student’s t-test (two-sided). P values = 0.0019, 1e-12, 0.056, 0.063, 9.4e-5, 4.9e-13 from left to right.