Extended Data Fig. 7: Characterization of six CRC groups and validation of classification and cell-cell interaction. | Nature Cancer

Extended Data Fig. 7: Characterization of six CRC groups and validation of classification and cell-cell interaction.

From: Integrative single-cell analysis of human colorectal cancer reveals patient stratification with distinct immune evasion mechanisms

Extended Data Fig. 7

(a) Density plot showing the distribution of group 6 signature score in TCGA patients, n = 87 (MSI) and 193 (MSS) samples. (b) Boxplots (top and bottom quartiles with horizontal lines at the median) showing the proportion of EMP1+ (left) and LGR5+ (right) malignant cells in patients of different groups, n = 7 (G1), 23 (G2), 10 (G3), 15 (G4), 25 (G5) and 30 (G6). Student’s t-test, (one-sided). (c) Violin plots showing iCMS marker genes score in different groups. n = 4, 23, 10, 14, 22, 21 and 53 patients. (d) Heatmap showing the relative abundance of cell subsets in the validation cohort. (e) Hematoxylin-eosin staining, ADGRE5 and CD55 expression in transcriptomic spots. This pattern was replicated in two patients. (f) Scatter plot showing correlation between expression density of ADGRE5 and CD55 in transcriptomic data. P value is less than the smallest non-zero normalized floating-point number of R, n = 4007. Pearson’s correlation.

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